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Integrating eCOAs and Digital Health Technologies for Patient-Centric Trials

The foundation of patient-first design is technology that connects seamlessly to support and meet patients where they are. In this session, leaders from Pfizer, THREAD, Datacubed, Obvio Health, and Merative will discuss how integrated digital ecosystems are breaking down platform and industry silos, enhancing engagement, improving access, and scaling across therapeutic areas. Learn how pharma and tech companies are expanding digital endpoints and paving the way for the next...

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Translation and Cultural Adaptation of Clinical Outcome Assessments (COAs): Is Machine Translation a Viable Option?

As technology continues to advance and the need to expedite drug development increases, the applications of Machine Translation (MT) and Artificial Intelligence (AI) in the translation process should be further explored. The capabilities of iterative learning and feedback can serve as a tool for translation, but the limitations should be considered. This poster will compare human translation (HT) and machine translation (MT) in the back translation step for Clinical Outcome...

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Keeping Patients at the Heart of Clinical Trials

Clinical trial patient recruitment continues to be challenging. Even with shifts to decentralize clinical trials and the addition of new vendors and technology, recruitment still is the primary cause of delays or discontinuation. What could we be missing? In this webinar, we’ll discuss the current state of clinical trials, historical challenges of recruitment, and new thinking to integrate human touch and improve retention. We will share frameworks and methodologies you...

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ISPOR Europe 2020 Virtual Poster - Usability Testing for eCOAs

In order to ensure a fluid experience for a patient, usability testing is a critical data point to consider. Addressing both a patient’s needs and access to a digital platform is key to data collection. TransPerfect, along with our partners from Parexel, Clinical Ink, and Health Psychology Research, recently published a poster at the Virtual ISPOR Europe 2020 conference that reviews the impact of moving from in-person to electronic data collection....

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LifeSci Talks COA Series | Breaking the Hype Cycle: An Objective Look at Remote Research Strategies in DCTs

In the first part of TransPerfect's latest LifeSci Talks episode, Mark Wade, Global Practice Leader at TransPerfect Life Sciences, with guest Dr. Michelle Longmire, CEO of Medable, spoke about how a Stanford doctor transitioned into a career of entrepreneurship, creating a multimillion dollar eClinical company. Continuing the conversation in part two, the pair explore the commercial aspects of e-clinical solutions, particularly focusing on the landscape of Decentralized...

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LifeSci Talks COA Series | Exploring the Intersection of Clinical Practice and Entrepreneurship: Technological Innovation in Clinical Research

In this episode of TransPerfect LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences, sits down with Dr Michelle Longmire, CEO of Medable, to discuss her journey from clinical practice to entrepreneurship, driven by a passion for rare disease, and the need for technological innovation in clinical research. The conversation highlights key challenges faced in transitioning from academia to entrepreneurship, and the importance of storytelling in...

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LifeSci Talks COA Series | Balancing Innovation and Integrity: AI’s Place in Patient-Focused Research

Artificial intelligence is redefining what’s possible across the clinical development lifecycle, but with rapid innovation comes the need for thoughtful oversight. In this episode of LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences, sits down with Richard “RJ” Kedziora, Co-Founder of Estenda Solutions, to explore how AI is transforming clinical research and digital health. From scaling informed consent through digital avatars to detecting patient...

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Lessons Learned in the Rush for a Vaccine and the Effects on Language Translation: Creating and Adapting Technologies

The rush to a vaccine has accelerated an already dynamic research process. This has led to many innovations and an evolution of procedures. The language translation industry has seen enormous stressors and has had to create and modify processes and technologies similarly. The pandemic has changed society profoundly. The disruption in human and business interactions have not only affected the travel, conference, and hospitality industries but has also changed the clinical...

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LifeSci Talks COA Series | Data Without Interpretation is Meaningless: Unlocking Inherent Value Within the Numbers

In this episode of LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences, sits down with Elizabeth (Nicki) Bush, Executive Director and Global Head of Endpoint Strategy and COA Measurement at OPEN Health Group to discuss the growing complexity of collecting and interpreting patient data. With insights from the recent FDA workshop around Patient-Focused Drug Development (PFFD), the two discuss the importance of integrating measurement science early in...

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LifeSci Talks COA Series | Decoding Decentralized Trials: Navigating Novel Decentralized Research Challenges and Complexity

DCTs have picked up significantly in previous years, catalyzed by the pandemic and a move to remote research. With this move comes a host of new challenges, including those surrounding technical interoperability, resistance to adopting new technologies, and the need for flexibility in technology uptake at research sites. With additional considerations to be made, such as ensuring regulatory compliance, and enforcing standardized metrics in assessing DCT performance, this...

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LifeSci Talks COA Series | Exploring the Value Add of In-Study Interviews as a Critical COA Endpoint

In this episode of TransPerfect LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences sits down with Tom Willgoss, Patient-Centered Outcomes Research Chapter Lead, UK Site Head for Data Sciences at Roche to discuss the value of understanding and measuring patient experience data throughout the clinical journey. They delve into the significance of patient-centered clinical outcome assessments for endpoint selection in clinical trials, prioritizing...

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LifeSci Talks COA Series | Data Science: The New Frontier

In this episode of LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences sits down with Dr. Elizabeth Bacci, Senior Research Scientist at Evidera, to discuss critical aspects of developing meaningful and relevant Digital Health instruments. The conversation emphasizes the importance of aligning digital health tools with individual patient needs, and prioritizing the patient's perspective when developing instruments that are fit for purpose in...

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LifeSci Talks COA Series | Harnessing Implementation Science to Improve Health Outcomes: Methods and Approaches for the Future

Implementation science emerged as a response to the recognition that many effective health interventions and innovations were not being widely adopted or sustained in practice, even when evidence of their efficacy was strong. Join Meredith Smith, Senior Director of Implementation Science of Evidera in conversation with Mark Wade, Global Practice Leader of TransPerfect Life Sciences, as they explore the field of implementation science and its role in improving the translation...

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LifeSci Talks COA Series | Meaningful Patient Involvement in HTA Decision-making: Where do we go from here?

In this episode of LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences, sits down with Alice Biggane, Outcomes Innovation and Research Lead at Pfizer, to discuss how PRO measures inform and impact endpoint adjudication and reimbursement decisions, due to the lack of HRQoL data included. Together they unpack other methods that can be used for augmenting the quantification with regards to HRQoL, and the complex interplay between more general Measures...

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LifeSci Talks COA Series | Silver Bullet or Useful Repositories: The Reality of Clinical Trial Libraries

In this episode of LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences, is joined by Jonathan Norman, Director of Translation and Localization at YPrime, for an in-depth discussion on the realities of eCOA libraries. Together, they explore why “libraries” are more accurately described as asset repositories, the conditions under which reuse can meaningfully accelerate study timelines, and the limitations that prevent them from being a universal...

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LifeSci Talks | Effective Rater Training: A Critical but Overlooked Part of COA Administration

In this episode of LifeSci Talks, TransPerfect Life Sciences’ Global Practice Leader Mark Wade sits down with Kelly Dumais PhD, Director of eCOA Science at Clario to discuss the significance rater training plays in standardizing the administration and scoring of clinical scales. Aiming to reduce bias and enhance data quality, you’ll hear about potential strategies for better engaging patients and how comprehensive proactive training can reduce patient and site burden. Listen...

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LifeSci Talks COA Series | Modernizing eCOA: Emulators, Backups, and the Future of Reporting

In this tech-forward episode of LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences, welcomes Indira Jain-Figueroa, Product Director at Evinova, for a deep dive into the ever-evolving landscape of eCOA development. Covering everything from cross-platform development, backups, and emulator use to the future role of AI in reporting, this conversation highlights how innovation can improve both user experience and study efficiency in clinical trials....

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LifeSci Talks COA Series | From Interview to Endpoint: Understanding the Importance of Patient Listening to Build Better Outcomes

In this episode of TransPerfect LifeSci Talks, Mark Wade, Global Practice Leader at TransPerfect Life Sciences sits down with John Reites, Co-Founder and CEO of THREAD research to discuss the importance of patient listening to build better clinical trial endpoints. They delve into the differences between enterprise and standalone solutions, challenges with standardization, and the influence of evolving technologies in the eCOA industry. ...

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MedTech Summit EU 2024 | What's Past is Prologue: Evolution (and Future) of AI and Content Automation

Content automation technologies have been developing for 70 years – MDR and IVDR have accelerated this development, as well as adoption across the device industry. And, while product-related applications for artificial intelligence (AI) generate attention-grabbing headlines, the larger (and more certain) financial benefits are in process-related applications. So the question remains: How are translation AI and process automation software (CCMS, TMS) converging to automate...

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LifeSci Talks | Measuring What Matters: Modernizing Clinical Outcome Assessments with Patient-Centric Approaches

In this episode of LifeSci Talks, TransPerfect’s Global Practice Leader Mark Wade sits down with Dr. Karl McEvoy, VP of eCOA and Patient Technology at YPrime, to discuss the importance of embracing technology in clinical research to reduce the patient burden. The two cover everything from updating legacy instruments to more modern solutions such as using video assessments, to incorporating caregiver and patient advocacy groups input for reshaping trial design. Listen in for...